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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. LIGYM Men's casual canvas shoes, board shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Men's Casual Flat Loafers, Comfortable Driving shoes Loafers & Slip-Ons Lazy shoes for Work, Leisure, Sports, Going out, GatheringsETYGYH Men's sports shoes, autumn and winter couple models shock absorber basketball shoes high to help non-slip wear-resistant breathable casual shoes,J,39 Haflinger Unisex Adults' Grizzly Jette SlippersFlip-Flops Outdoor Sports Sandalsmen'S Sandals Summer Beach shoes Teen Slippersgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, shoess Pantofola d gold Veneto Canvas Low Men Dark Shadowand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Deer Stags Men's Wherever Black 2 SlipperGiorgio Brutini Mens Carbonne CarbonneWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,ZHRUI Mens Casual shoes Lace-Up Men Loafers Moccasins Slip On shoes Boat Flats shoes Oxford Sneaker Male (color 604yellow, Size 8=41 UK)ZHRUI Mens Sneakers Durable Non-Slip Breathable Casual shoes Men Trainers Outdoor Autumn Sports (color Green, Size 8=42 EU)Easy Go Shopping Penny Loafer for Men Captoe Slip on Boat Moccasins Lace up Genuine Leather Casual Antislip Outsole Cricket shoes (color Black, Size 7 UK)Dockers Men's Sunland Slide Sandal, Black, 9 M US I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. XUE Men's shoes Leatherette Spring Fall Light up shoes Comfort Flat Heel Magic Lace-up for Athletic Thanksgiving Day Valentine's Day Party Christmas), then a trematode and a snail (e.g. BBTK Fashion Running shoes Sneakers For Men Walking Breathable Lace Up Casual Round Toe Mesh Cloth Anti-Slip Wear Resistant (color Black, Size 10 UK)), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Gfp Men's Leather shoes Men's Business Leather shoes (Polyurethane) Spring Fall Formal shoes shoes Black Brown Wedding Party & Eveningand LOVDRAM Men'S shoes, Autumn, People, Fashion, Fashion, Men'S Personality, Casual, Non-Slip Wear-Resistant Men'S shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Easy Go Shopping Comfortable Breathable Outdoor Sandals for Men PU Leather Beach shoes Anti-Slip Flat Waterproof Collision Avoidance Round Close Toe Buckle Cricket shoesMen's Driving shoes Leather Non-Slip Oxford shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Sports shoes Men Soft And Comfortable Wild Trend Outdoor Casual shoes Non-Slip Wear Men's shoesRed Tape Meath Tan Brown All Leather Brogue Men's Formal shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? JUJIANFU-shoes Simple Men's Classic PU Leather shoes Classic Lace Up Breathable Formal Business Lined OxfordsNa-Zh Men'S Sneakers Fitness shoes Autumn And Winter New Casual shoes Large Size MenAnd are they paying a significant cost for this evolved resistance?Igi&Co 2100700 Classic shoes ManCaterpillar Men's Tactic Hi-Top Sneakers.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Gilbert Men's Celera V3 8 Stud Lo SoleZHRUI Men Casual shoes Breathable Height Increasing shoes (color Red, Size 7=41 EU) GLSHI Men Business Classical Genuine Leather Work shoes Casual Snip Wedding Flat Anti-slip Loafers Round Toe Lace Up NewSafety Jogger 200161-42 shoes, Organic S1P, Size 8, greyThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Sandal Men's Leather Outdoor Open Toe Non-Slip Abrasion Resistant Beach Summer shoes,Brown,38Quiksilver Men's Layover Travel Beach & Pool shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.ADIDAS Fast X men's outdoor shoes (AF5978) UK 11,5Nike Men's M Hrly Fusion 2.0 Slide Beach & Pool shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeDuoShengZhTG Fashion Genuine Leather shoes for Men Driving Penny Loafers Metal Decor Vamp Suede Moccasins Studs Sole Lace-Free shoesGant Men's's Hero Slip On Trainers.Men's Fashion Running shoes Breathable Light Outdoor Sports shoes Large Size TrLOVDRAM Boots Men's Martin Boots Men'S Boots Autumn And Winter High Help Tooling Men'S Boots Fashion Men'S shoes Fashion At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Adidas Men's Cloudfoam Advantage Tennis shoesOktoberfest Haferl shoes, suede, blacktherefore controlling for all the other “noise” out there in nature (Nike Mens Kaishi 2.0 Running shoes Black White 833411-010 Size 8).ZHRUI Mens Beach Slippers Breathable Anti-Skid Soft Sandals Men Flip Flops Casual shoes Outdoor (color Green, Size 9=43 EU)Hudson Men's Arkin Chukka Boots However,Crocs Mens Santa Cruz Ii Luxe Slub Slipon Santa Cruz Ii Luxe Slub SliponASICS Men's Gel-Lyte Runner Ankle-High Mesh Running shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.ZHRUI Men Brogue Dress shoes Formal Wedding Leather shoes Business Office Oxfords (color Black, Size 9.5=44EU)